44577
Fluka
Doxycycline hyclate
BioChemika, ≥98.0% (TLC)
| Synonym: | Doxycycline hydrochloride hemiethanolate hemihydrate |
| CAS Number: | 24390-14-5 |
| Linear Formula: | C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O |
| Molecular Weight: | 512.94 |
| Beilstein Registry Number: | 5702728 |
| MDL number: | MFCD07357237 |
Description
| Biochem/physiol Actions | Broad spectrum antibiotic; derivative of oxytetracycline. Broad spectrum inhibitor of matrix metalloproteinases in vivo. |
Properties
| product line | BioChemika |
| assay | ≥98.0% (TLC) |
| total impurities | ≤5% water |
| ≤7% ethanol | |
| solubility | H2O: 50 mg/mL, clear, yellow-green |
Safety
Related Products
| Replaced by | D9891, Doxycycline hyclate |
References
| reference | Burggraf, D. et al.,, Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol. Dis. 25, 506-13, (2007) |
| Franco, C. et al.,, Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am. J. Pathol. 168, 1697-709, (2006) | |
| Garcia, R.A. et al.,, Molecular interactions between matrilysin and the matrix mettalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol. Pharmacol. 67, 1128-36, (2005) | |
| Lamparter, S. et al.,, Doxycline and tissue repair in rats. J. Lab. Clin. Med. 139, 295-302, (2002) |
